Abstract
The tumorigenic activities in mouse lung of the tobacco-specific nitrosamines, N′-nitrosonornicotine (NNN), 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and several structural analogues were evaluated. The analogues were N-nitrosopyrrolidine (NPYR), 5′-carboxy-N′-nitrosonornicotine (CNNN), N-nitrosoproline (NPRO) and 1-(3-pyridyl)-2-buten-1-one (PBO). The results were as follows (dose in μmol per mouse/lung tumors per mouse): NNN ( 100 1.8 ± 1.4); NPYR ( 100 3.9 ± 1.5); CNNN ( 200 0.3 ± 0.5); CNNN ( 100 0.5 ± 0.6); NPRO ( 100 0.6 ± 0.7); NNK ( 20 7.2 ± 3.4); PBO ( 20 0.7 ± 1.0); saline control (0.05 ± 0.7). Several conclusions were drawn from this assay. NNK and NPYR were more tumorigenic than NNN. CNNN was non-tumorigenic and thus appears to have potential as a monitor for endogenous formation of tobacco-specific nitrosamines. The α,β-unsaturated ketone PBO does not appear to be an ultimate tumorigen of NNK or NNN.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-145 |
| Number of pages | 5 |
| Journal | Cancer Letters |
| Volume | 42 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 1988 |
Bibliographical note
Funding Information:We thank Chang-In Choi and Laura Quattrocci for their technical assistance. This paper is dedicated to the memory of Aziz Abbaspour who did the initial research on this project and passed away April 7, 1987. Supported by grants 29580 and 44377 from the National Cancer Institute.
Keywords
- 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, N′-nitrosonornicotine
- 5′-carboxy-N′-nitrosonornicotine
- N-nitrosoproline
- N-nitrosopyrrolidine
- lung adenoma
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