A study of tobacco carcinogenesis XLII. Bioassay in mice of some structural analogues of tobacco-specific nitro samines

S. S. Hecht, A. Abbaspour, D. Hoffman

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39 Scopus citations

Abstract

The tumorigenic activities in mouse lung of the tobacco-specific nitrosamines, N′-nitrosonornicotine (NNN), 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and several structural analogues were evaluated. The analogues were N-nitrosopyrrolidine (NPYR), 5′-carboxy-N′-nitrosonornicotine (CNNN), N-nitrosoproline (NPRO) and 1-(3-pyridyl)-2-buten-1-one (PBO). The results were as follows (dose in μmol per mouse/lung tumors per mouse): NNN ( 100 1.8 ± 1.4); NPYR ( 100 3.9 ± 1.5); CNNN ( 200 0.3 ± 0.5); CNNN ( 100 0.5 ± 0.6); NPRO ( 100 0.6 ± 0.7); NNK ( 20 7.2 ± 3.4); PBO ( 20 0.7 ± 1.0); saline control (0.05 ± 0.7). Several conclusions were drawn from this assay. NNK and NPYR were more tumorigenic than NNN. CNNN was non-tumorigenic and thus appears to have potential as a monitor for endogenous formation of tobacco-specific nitrosamines. The α,β-unsaturated ketone PBO does not appear to be an ultimate tumorigen of NNK or NNN.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalCancer Letters
Volume42
Issue number1-2
DOIs
StatePublished - Jan 1 1988

Keywords

  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, N′-nitrosonornicotine
  • 5′-carboxy-N′-nitrosonornicotine
  • N-nitrosoproline
  • N-nitrosopyrrolidine
  • lung adenoma

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