A study of tobacco carcinogenesis. XIV. Effects of N' nitrosonornicotine and N' nitrosonanabasine in rats

D. Hoffmann; R. Raineri; S. S. Hecht; R. Maronpot; E. L. Wynder

doi:10.1093/jnci/55.4.977

A study of tobacco carcinogenesis. XIV. Effects of N' nitrosonornicotine and N' nitrosonanabasine in rats

D. Hoffmann, R. Raineri, S. S. Hecht, R. Maronpot, E. L. Wynder

Laboratory Medicine and Pathology

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Abstract

N' Nitrosonornicotine (NNN) and N' nitrosoanabasine (NAB) were synthesized and administered in drinking water to male Fischer rats for 30 weeks (total dose, 630 mg). 1,4 Dinitrosopiperazine (DNPI) served as the positive control. By 11 mth, all surviving rats given NNN developed esophageal tumors (12/20); 1 had a pharyngeal tumor and 3 had invasive carcinomas originating in the nasal cavity. During the same time, only 1 of 20 rats given NAB developed esophageal tumors. Compared to the strong esophageal carcinogen DNPI, NNN was a moderately active and NAB a weak carcinogen. NNN (0.3-90 parts per million) in chewing tobacco was related to the observation that cancer of the oral cavity and esophagus in man is correlated with the chewing of tobacco.

Original language	English (US)
Pages (from-to)	977-981
Number of pages	5
Journal	Unknown Journal
Volume	55
Issue number	4
DOIs	https://doi.org/10.1093/jnci/55.4.977
State	Published - 1975

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abstract = "N' Nitrosonornicotine (NNN) and N' nitrosoanabasine (NAB) were synthesized and administered in drinking water to male Fischer rats for 30 weeks (total dose, 630 mg). 1,4 Dinitrosopiperazine (DNPI) served as the positive control. By 11 mth, all surviving rats given NNN developed esophageal tumors (12/20); 1 had a pharyngeal tumor and 3 had invasive carcinomas originating in the nasal cavity. During the same time, only 1 of 20 rats given NAB developed esophageal tumors. Compared to the strong esophageal carcinogen DNPI, NNN was a moderately active and NAB a weak carcinogen. NNN (0.3-90 parts per million) in chewing tobacco was related to the observation that cancer of the oral cavity and esophagus in man is correlated with the chewing of tobacco.",

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T1 - A study of tobacco carcinogenesis. XIV. Effects of N' nitrosonornicotine and N' nitrosonanabasine in rats

AU - Hoffmann, D.

AU - Raineri, R.

AU - Hecht, S. S.

AU - Maronpot, R.

AU - Wynder, E. L.

PY - 1975

Y1 - 1975

N2 - N' Nitrosonornicotine (NNN) and N' nitrosoanabasine (NAB) were synthesized and administered in drinking water to male Fischer rats for 30 weeks (total dose, 630 mg). 1,4 Dinitrosopiperazine (DNPI) served as the positive control. By 11 mth, all surviving rats given NNN developed esophageal tumors (12/20); 1 had a pharyngeal tumor and 3 had invasive carcinomas originating in the nasal cavity. During the same time, only 1 of 20 rats given NAB developed esophageal tumors. Compared to the strong esophageal carcinogen DNPI, NNN was a moderately active and NAB a weak carcinogen. NNN (0.3-90 parts per million) in chewing tobacco was related to the observation that cancer of the oral cavity and esophagus in man is correlated with the chewing of tobacco.

AB - N' Nitrosonornicotine (NNN) and N' nitrosoanabasine (NAB) were synthesized and administered in drinking water to male Fischer rats for 30 weeks (total dose, 630 mg). 1,4 Dinitrosopiperazine (DNPI) served as the positive control. By 11 mth, all surviving rats given NNN developed esophageal tumors (12/20); 1 had a pharyngeal tumor and 3 had invasive carcinomas originating in the nasal cavity. During the same time, only 1 of 20 rats given NAB developed esophageal tumors. Compared to the strong esophageal carcinogen DNPI, NNN was a moderately active and NAB a weak carcinogen. NNN (0.3-90 parts per million) in chewing tobacco was related to the observation that cancer of the oral cavity and esophagus in man is correlated with the chewing of tobacco.

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A study of tobacco carcinogenesis. XIV. Effects of N' nitrosonornicotine and N' nitrosonanabasine in rats

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