A study of chemical carcinogenesis: Comparative carcinogenicity of 5-methylchrysene, benzo(a)pyrene, and modified chrysenes

Stephen S. Hecht, Myrna Loy, Robert R. Maronpot, Dietrich Hoffmann

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The carcinogenic activity of 5-methylchrysene (5-MeC) was assayed in the connective tissue of C-57 black mice, and 5-MeC was compared to benzo(a)pyrene (BaP) and certain modified chrysene derivatives for tumorigenic activity on mouse skin. Subcutaneous injections of 5-MeC (total dose, 0.5 mg) resulted in 22 sarcoma-bearing animals in a group of 25. On mouse skin, 5-MeC and BaP had comparable complete carcinogenic activity, and 5-MeC was a stronger tumor initiator than BaP. Compared to 5-MeC, 12-fluoro-5-methylchrysene was a weaker tumor initiator on mouse skin, while 5-methoxychrysene was somewhat less active. 1-Fluoro-4-methylchrysene and 6-methoxy-5-methylchrysene lacked significant tumor-initiating activity. The bioassay data are discussed in respect to the steric and electronic features of the chrysene ring system.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalCancer Letters
Volume1
Issue numberC
DOIs
StatePublished - 1975

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