A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity

Michael D. Harries; Samuel R. Chamberlain; Sarah A. Redden; Brian L. Odlaug; Austin W. Blum; Jon E. Grant

doi:10.1016/j.pscychresns.2017.09.006

A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity

Michael D. Harries, Samuel R. Chamberlain, Sarah A. Redden, Brian L. Odlaug, Austin W. Blum, Jon E. Grant

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Excoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life. No statistically significant differences in basal ganglia (caudate, putamen, and nucleus accumbens) structural volumes were found between groups. In individuals with SPD, increasing impulsiveness correlated positively with increased cortical thickness in the left insula, and skin picking severity correlated negatively with cortical thickness in the left supramarginal gyrus and a region encompassing the right inferior parietal, right temporal and right supramarginal gyrus. This study suggests similarities and differences exist in symptomology between SPD and the other obsessive-compulsive and related disorders. Additional neuroimaging research is needed to better delineate the underlying neurobiology of SPD.

Original language	English (US)
Pages (from-to)	26-30
Number of pages	5
Journal	Psychiatry Research - Neuroimaging
Volume	269
DOIs	https://doi.org/10.1016/j.pscychresns.2017.09.006
State	Published - Nov 30 2017
Externally published	Yes

Bibliographical note

Funding Information:
Mr. Michael Harries, Ms. Sarah Redden and Mr. Austin Blum report no conflicts of interest. Dr. Samuel Chamberlain consults for Cambridge Cognition and Shire. He also receives funding from the Wellcome Trust Clinical Fellowship ( 110049/Z/15/Z ). Dr. Brian Odlaug has received research funding from the TLC Foundation for Body Focused Repetitive Behaviors and has received royalties from Oxford University Press and Johns Hopkins Press. He has consulted for and is currently employed by H. Lundbeck A/S. His contribution to this project concluded prior to his employment with H. Lundbeck A/S. Dr. Jon Grant currently has research grants from the National Center for Responsible Gaming , Brainsway, the American Foundation for Suicide Prevention , the TLC Foundation for Body Focused Repetitive Behaviors , Forest Takeda and Psyadon Pharmaceuticals . He receives yearly compensation from Springer Publishing for acting as Editor-in-Chief of the Journal of Gambling Studies and has received royalties from Oxford University Press, Johns Hopkins Press, American Psychiatric Publishing, Inc., Norton Press, and McGraw Hill.

Publisher Copyright:
© 2017 Elsevier B.V.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

Brain imaging
Cortical thickness
Obsessive-compulsive
Skin picking disorder
Structural volume

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title = "A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity",

abstract = "Excoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life. No statistically significant differences in basal ganglia (caudate, putamen, and nucleus accumbens) structural volumes were found between groups. In individuals with SPD, increasing impulsiveness correlated positively with increased cortical thickness in the left insula, and skin picking severity correlated negatively with cortical thickness in the left supramarginal gyrus and a region encompassing the right inferior parietal, right temporal and right supramarginal gyrus. This study suggests similarities and differences exist in symptomology between SPD and the other obsessive-compulsive and related disorders. Additional neuroimaging research is needed to better delineate the underlying neurobiology of SPD.",

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A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity

Abstract

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Keywords

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