A structural and functional model for dioxygenases with a 2-His-1-carboxylate triad

Paul D. Oldenburg, Chun Yen Ke, A. Alex Tipton, Albert A. Shteinman, Larry Que

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

(Chemical Equation Presented) An attractive model: The iron complex shown on the left models the 2-His-1-carboxylate active sites of Rieske dioxygenases both in terms of structure and function. 18O-labeling studies of olefin dihydroxylation support the involvement of a high-valent iron-oxo species.

Original languageEnglish (US)
Pages (from-to)7975-7978
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number47
DOIs
StatePublished - Dec 4 2006

Keywords

  • Dihydroxylation
  • Dioxygenases
  • Enzyme models
  • Epoxidation
  • Oxidation

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