A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Matthew B. Buechler, Ki Wook Kim, Emily J. Onufer, Jesse W Williams, Christine C. Little, Claudia X. Dominguez, Qingling Li, Wendy Sandoval, Jonathan E. Cooper, Charles A. Harris, Melissa R. Junttila, Gwendalyn J. Randolph, Shannon J. Turley

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.

Original languageEnglish (US)
Pages (from-to)119-130.e5
JournalImmunity
Volume51
Issue number1
DOIs
StatePublished - Jul 16 2019
Externally publishedYes

Fingerprint

Homeostasis
Transcription Factors
Macrophages
Tretinoin
GATA6 Transcription Factor
Stromal Cells
Transcriptome

Keywords

  • Fibroblasts
  • Macrophages
  • Mesothelial cells
  • Retinoic acid
  • WT1

PubMed: MeSH publication types

  • Journal Article

Cite this

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages. / Buechler, Matthew B.; Kim, Ki Wook; Onufer, Emily J.; Williams, Jesse W; Little, Christine C.; Dominguez, Claudia X.; Li, Qingling; Sandoval, Wendy; Cooper, Jonathan E.; Harris, Charles A.; Junttila, Melissa R.; Randolph, Gwendalyn J.; Turley, Shannon J.

In: Immunity, Vol. 51, No. 1, 16.07.2019, p. 119-130.e5.

Research output: Contribution to journalArticle

Buechler, MB, Kim, KW, Onufer, EJ, Williams, JW, Little, CC, Dominguez, CX, Li, Q, Sandoval, W, Cooper, JE, Harris, CA, Junttila, MR, Randolph, GJ & Turley, SJ 2019, 'A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages', Immunity, vol. 51, no. 1, pp. 119-130.e5. https://doi.org/10.1016/j.immuni.2019.05.010
Buechler, Matthew B. ; Kim, Ki Wook ; Onufer, Emily J. ; Williams, Jesse W ; Little, Christine C. ; Dominguez, Claudia X. ; Li, Qingling ; Sandoval, Wendy ; Cooper, Jonathan E. ; Harris, Charles A. ; Junttila, Melissa R. ; Randolph, Gwendalyn J. ; Turley, Shannon J. / A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages. In: Immunity. 2019 ; Vol. 51, No. 1. pp. 119-130.e5.
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