A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity

Lindsey A. Ingerman; Matthew E. Cuellar; Marcey L. Waters

doi:10.1039/c000255k

A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity

Lindsey A. Ingerman
, Matthew E. Cuellar
, Marcey L. Waters

Institute for Therapeutics Discovery and Development

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

A small molecule receptor that mimics the HP1 chromodomain's affinity for trimethyl lysine has been identified from a dynamic combinatorial library. Discrimination for trimethyl lysine over the lower methylation states parallels that of the native protein receptor. These studies demonstrate the feasibility of small molecule receptors as potential sensors for protein posttranslational modifications.

Original language	English (US)
Pages (from-to)	1839-1841
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	11
DOIs	https://doi.org/10.1039/c000255k
State	Published - Mar 19 2010

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title = "A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity",

abstract = "A small molecule receptor that mimics the HP1 chromodomain's affinity for trimethyl lysine has been identified from a dynamic combinatorial library. Discrimination for trimethyl lysine over the lower methylation states parallels that of the native protein receptor. These studies demonstrate the feasibility of small molecule receptors as potential sensors for protein posttranslational modifications.",

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AU - Cuellar, Matthew E.

AU - Waters, Marcey L.

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AB - A small molecule receptor that mimics the HP1 chromodomain's affinity for trimethyl lysine has been identified from a dynamic combinatorial library. Discrimination for trimethyl lysine over the lower methylation states parallels that of the native protein receptor. These studies demonstrate the feasibility of small molecule receptors as potential sensors for protein posttranslational modifications.

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UR - https://www.scopus.com/pages/publications/77949416398#tab=citedBy

U2 - 10.1039/c000255k

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AN - SCOPUS:77949416398

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SP - 1839

EP - 1841

JO - Chemical Communications

JF - Chemical Communications

IS - 11

ER -

A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity

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