A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity

Lindsey A. Ingerman, Matthew E. Cuellar, Marcey L. Waters

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

A small molecule receptor that mimics the HP1 chromodomain's affinity for trimethyl lysine has been identified from a dynamic combinatorial library. Discrimination for trimethyl lysine over the lower methylation states parallels that of the native protein receptor. These studies demonstrate the feasibility of small molecule receptors as potential sensors for protein posttranslational modifications.

Original languageEnglish (US)
Pages (from-to)1839-1841
Number of pages3
JournalChemical Communications
Volume46
Issue number11
DOIs
StatePublished - Mar 19 2010

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