TY - JOUR
T1 - A simulation study on superparamagnetic nanoparticle based multi-tracer tracking
AU - Wu, Kai
AU - Batra, Akash
AU - Jain, Shray
AU - Ye, Clark
AU - Liu, Jinming
AU - Wang, Jian Ping
N1 - Publisher Copyright:
© 2015 AIP Publishing LLC.
PY - 2015/10/26
Y1 - 2015/10/26
N2 - Superparamagnetic nanoparticles (MNPs) have been utilized in biomedical sensing, detection, therapeutics, and diagnostics due to their unique magnetic response under different driving fields. In this letter, we report a multi-tracer tracking method that uses different kinds of MNPs as magnetic tracers along with two alternating magnetic fields that can be potentially used to build magnetic-based flow cytometry. By applying two driving fields at frequency f H and f L to MNPs, the response signal is measured at the combinatorial frequencies such as fH ± 2 fL(3rd harmonics), fH ± 4 f L (5th harmonics), fH ± 6 f L (7th harmonics), and so on. Each MNP has its own signature of phase and amplitude, and it is possible to differentiate individual MNPs in a mixture. We theoretically demonstrated colorizing up to 4-MNP tracers in one mixture with an error rate lower than 10%. The performance of multi-tracer imaging can be optimized by increasing the driving field frequency, choosing MNPs with higher saturation magnetization, and using MNP tracers with more centralized size distribution.
AB - Superparamagnetic nanoparticles (MNPs) have been utilized in biomedical sensing, detection, therapeutics, and diagnostics due to their unique magnetic response under different driving fields. In this letter, we report a multi-tracer tracking method that uses different kinds of MNPs as magnetic tracers along with two alternating magnetic fields that can be potentially used to build magnetic-based flow cytometry. By applying two driving fields at frequency f H and f L to MNPs, the response signal is measured at the combinatorial frequencies such as fH ± 2 fL(3rd harmonics), fH ± 4 f L (5th harmonics), fH ± 6 f L (7th harmonics), and so on. Each MNP has its own signature of phase and amplitude, and it is possible to differentiate individual MNPs in a mixture. We theoretically demonstrated colorizing up to 4-MNP tracers in one mixture with an error rate lower than 10%. The performance of multi-tracer imaging can be optimized by increasing the driving field frequency, choosing MNPs with higher saturation magnetization, and using MNP tracers with more centralized size distribution.
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U2 - 10.1063/1.4934743
DO - 10.1063/1.4934743
M3 - Article
AN - SCOPUS:84945921472
SN - 0003-6951
VL - 107
JO - Applied Physics Letters
JF - Applied Physics Letters
IS - 17
M1 - 173701
ER -