A simple tool to predict outcomes after kidney transplant

Bertram L. Kasiske, Ajay K. Israni, Jon J. Snyder, Melissa A. Skeans, Yi Peng, Eric D. Weinhandl

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Background Surprisingly few tools have been developed to predict outcomes after kidney transplant. Study Design Retrospective observational cohort study. Setting & Participants Adult patients from US Renal Data System (USRDS) data who underwent deceased donor kidney transplant in 2000-2006. Predictor Full and abbreviated prediction tools for graft loss using candidate predictor variables available in the USRDS registry, including data from the Organ Procurement and Transplantation Network and the Centers for Medicare & Medicaid Services End-Stage Renal Disease Program. Outcomes Graft loss within 5 years, defined as return to maintenance dialysis therapy, preemptive retransplant, or death with a functioning graft. Measurements We used Cox proportional hazards analyses to develop separate tools for assessment (1) pretransplant, (2) at 7 days posttransplant, and (3) at 1 year posttransplant to predict subsequent risk of graft loss within 5 years of transplant. We used measures of discrimination and explained variation to determine the number of variables needed to predict outcomes at each assessment time in the full and abbreviated equations, creating simple user-friendly prediction tools. Results Although we could identify 32, 29, and 18 variables that predicted graft loss assessed pretransplant and at 7 days and 1 year posttransplant ("full" models), 98% of the discriminatory ability and >80% of the variability explained by the full models could be achieved using only 11, 8, and 6 variables, respectively. Limitations Comorbidity data were from the Centers for Medicare & Medicaid Medical Evidence Report, which may significantly underreport comorbid conditions; C statistic values may indicate only modest ability to discriminate risk for an individual patient. Conclusions This method produced risk-prediction tools that can be used easily by patients and clinicians to aid in understanding the absolute and relative risk of graft loss within 5 years of transplant.

Original languageEnglish (US)
Pages (from-to)947-960
Number of pages14
JournalAmerican Journal of Kidney Diseases
Volume56
Issue number5
DOIs
StatePublished - Nov 1 2010

Keywords

  • Death-censored graft loss
  • Index Words
  • graft failure
  • mortality
  • registry analysis
  • risk prediction

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    Kasiske, B. L., Israni, A. K., Snyder, J. J., Skeans, M. A., Peng, Y., & Weinhandl, E. D. (2010). A simple tool to predict outcomes after kidney transplant. American Journal of Kidney Diseases, 56(5), 947-960. https://doi.org/10.1053/j.ajkd.2010.06.020