A simple molecular mathematical model of mammalian hibernation

Marshall E Hampton, Matthew T. Andrews

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A simple model of the dynamics of the body temperature of a hibernating mammal is presented. Our model provides a good match to experimental data, showing the interruption of low-temperature torpor bouts with periodic interbout arousals (IBAs). In this paper we present a mathematical model of the molecules that participate in the initiation, regulation, and maintenance of the hibernating state. This model can be used to describe the role of regulatory molecules, signal transducers, downstream target enzymes, structural proteins, or metabolites. Because many of the biochemical mechanisms are unknown, this is a preliminary and largely phenomenological model that we hope will inspire further investigation.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalJournal of Theoretical Biology
Issue number2
StatePublished - Jul 21 2007

Bibliographical note

Funding Information:
The work of M.T. Andrews was supported by NIH Grant HL-081100. The authors thank the reviewers of this article for their helpful comments and suggestions.


  • Hibernation
  • Interbout arousal


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