A simple and inexpensive method of evaluating particle settling rates and the particle size distribution of chromatographic supports using common laboratory equipment is reported. The time dependence of the turbidity of a solution of silica support particles suspended in an appropriate liquid is measured on a spectrometer. Digital acquisition allows data manipulation using simple algorithms to yield the distribution of particle sizes based on the Stoke's diameter. This data can easily be transformed into the most useful form for presentation, e.g. number average, weight average, cumulative distribution, etc.
Bibliographical noteFunding Information:
ACKNOWLEDGEMENTS Work in this paper has been funded in part by grants from the Minnesota Mining and Manufacturing Co., St. Paul, MN, and from the National Science Foundation (CHE 8217363).