A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER

Wenzheng He; Qifu Zhang; Changdong Zhou; Yang Lin; Xiongying Ye; Tianhong Cui

A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER

Wenzheng He
, Qifu Zhang
, Changdong Zhou
, Yang Lin
, Xiongying Ye
, Tianhong Cui

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We proposed a new wrinkle-based electrochemical sensor to detect prostate-specific antigen (PSA) for point-of-care (POC) diagnosing prostate cancer. The wrinkles were regulated by the polymer shrink technique with wavelengths from 200 nm to 4 μm, demonstrating different freedom degrees and sensitivities towards antigens and small molecules. A shrink sensor with 200 nm gold integrated into a portable system was validated by a label-free immunoassay for detection of PSA in 20 μL serum within 35 minutes and exhibited an ultralow limit of detection (0.38 fg/mL) and wide linear response (8 order of magnitude).

Original language	English (US)
Title of host publication	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	97-98
Number of pages	2
ISBN (Electronic)	9781733419048
State	Published - 2022
Event	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duration: Oct 23 2022 → Oct 27 2022

Publication series

Name	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Country/Territory	China
City	Hybrid, Hangzhou
Period	10/23/22 → 10/27/22

Bibliographical note

Publisher Copyright:
© 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bio-sensing
Point-of-care
Prostate-specific antigen
Shrinking polymer
Wrinkle

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He, W., Zhang, Q., Zhou, C., Lin, Y., Ye, X., & Cui, T. (2022). A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 97-98). (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER. / He, Wenzheng; Zhang, Qifu; Zhou, Changdong et al.
MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. p. 97-98 (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

He, W, Zhang, Q, Zhou, C, Lin, Y, Ye, X & Cui, T 2022, A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER. in MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 97-98, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022, Hybrid, Hangzhou, China, 10/23/22.

He W, Zhang Q, Zhou C, Lin Y, Ye X, Cui T. A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2022. p. 97-98. (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

He, Wenzheng ; Zhang, Qifu ; Zhou, Changdong et al. / A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER. MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. pp. 97-98 (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

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abstract = "We proposed a new wrinkle-based electrochemical sensor to detect prostate-specific antigen (PSA) for point-of-care (POC) diagnosing prostate cancer. The wrinkles were regulated by the polymer shrink technique with wavelengths from 200 nm to 4 μm, demonstrating different freedom degrees and sensitivities towards antigens and small molecules. A shrink sensor with 200 nm gold integrated into a portable system was validated by a label-free immunoassay for detection of PSA in 20 μL serum within 35 minutes and exhibited an ultralow limit of detection (0.38 fg/mL) and wide linear response (8 order of magnitude).",

keywords = "Bio-sensing, Point-of-care, Prostate-specific antigen, Shrinking polymer, Wrinkle",

author = "Wenzheng He and Qifu Zhang and Changdong Zhou and Yang Lin and Xiongying Ye and Tianhong Cui",

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AU - He, Wenzheng

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AU - Zhou, Changdong

AU - Lin, Yang

AU - Ye, Xiongying

AU - Cui, Tianhong

PY - 2022

Y1 - 2022

N2 - We proposed a new wrinkle-based electrochemical sensor to detect prostate-specific antigen (PSA) for point-of-care (POC) diagnosing prostate cancer. The wrinkles were regulated by the polymer shrink technique with wavelengths from 200 nm to 4 μm, demonstrating different freedom degrees and sensitivities towards antigens and small molecules. A shrink sensor with 200 nm gold integrated into a portable system was validated by a label-free immunoassay for detection of PSA in 20 μL serum within 35 minutes and exhibited an ultralow limit of detection (0.38 fg/mL) and wide linear response (8 order of magnitude).

AB - We proposed a new wrinkle-based electrochemical sensor to detect prostate-specific antigen (PSA) for point-of-care (POC) diagnosing prostate cancer. The wrinkles were regulated by the polymer shrink technique with wavelengths from 200 nm to 4 μm, demonstrating different freedom degrees and sensitivities towards antigens and small molecules. A shrink sensor with 200 nm gold integrated into a portable system was validated by a label-free immunoassay for detection of PSA in 20 μL serum within 35 minutes and exhibited an ultralow limit of detection (0.38 fg/mL) and wide linear response (8 order of magnitude).

KW - Bio-sensing

KW - Point-of-care

KW - Prostate-specific antigen

KW - Shrinking polymer

KW - Wrinkle

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M3 - Conference contribution

AN - SCOPUS:85175735531

T3 - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 97

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BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

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ER -

A SHRINK POLYMER ELECTROCHEMICAL SENSOR FOR POINT-OF-CARE DETECTION OF PROSTATE CANCER

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Keywords

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