Abstract
We proposed a new wrinkle-based electrochemical sensor to detect prostate-specific antigen (PSA) for point-of-care (POC) diagnosing prostate cancer. The wrinkles were regulated by the polymer shrink technique with wavelengths from 200 nm to 4 μm, demonstrating different freedom degrees and sensitivities towards antigens and small molecules. A shrink sensor with 200 nm gold integrated into a portable system was validated by a label-free immunoassay for detection of PSA in 20 μL serum within 35 minutes and exhibited an ultralow limit of detection (0.38 fg/mL) and wide linear response (8 order of magnitude).
| Original language | English (US) |
|---|---|
| Title of host publication | MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 97-98 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419048 |
| State | Published - 2022 |
| Event | 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duration: Oct 23 2022 → Oct 27 2022 |
Publication series
| Name | MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 |
|---|---|
| Country/Territory | China |
| City | Hybrid, Hangzhou |
| Period | 10/23/22 → 10/27/22 |
Bibliographical note
Publisher Copyright:© 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
Keywords
- Bio-sensing
- Point-of-care
- Prostate-specific antigen
- Shrinking polymer
- Wrinkle
