A Short-Term Enteral Nutrition Protocol for Management of Adult Crohn’s Disease—A Pilot Trial

Levi Teigen, Matthew Hamilton, Austin Hoeg, Lulu Chen, Sharon Lopez, Amanda Kabage, Priyali Shah, Eugenia Shmidt, Byron Vaughn

Research output: Contribution to journalArticlepeer-review

Abstract

Crohn’s disease (CD) is often treated with either exclusive or supplemental enteral nutrition (EN) in pediatrics, but adult practice guidelines primarily focus on medications. Here, we demonstrate the feasibility of a 4-week semi-elemental-formula-based oral nutrition delivery program for managing adult CD (n = 4). Patients consumed ~66% of calories from the formula, a finding that might provide an improved calorie target for future trials. We identified Flavinofractor as the only differentially abundant genus, distinguishing post-intervention samples from pre-intervention samples. Findings from this pilot trial demonstrate the feasibility of a partial enteral nutrition protocol in adult CD management and contribute to the growing body of literature on the potential role of EN therapy in adults with CD.

Original languageEnglish (US)
Article number1663
JournalJournal of Clinical Medicine
Volume13
Issue number6
DOIs
StatePublished - Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Keywords

  • Crohn’s disease
  • diet
  • microbiome
  • partial enteral nutrition

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