A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer

Chao Chen, Wenji Yao, Wen Sun, Tianyuan Guo, Hangya Lv, Xiaoli Wang, Hanjie Ying, Yibing Wang, Ping Wang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Surface modification and functionalization of nanomaterials have been adopted widely in devising smart drug delivery systems. This work examines the fabrication of multi-stimuli responsive surfaces on mesoporous silica nanoparticles (MSN) for environmentally sensitive site specific drug delivery with reduced risk of premature drug leakage. Chitosan cross-linked via disulfide bonds was applied to form a thin film on drug-loaded MSN, realizing a capsulation and stimuli-sensitive regulating gate membrane; that was further conjugated with folate for site specific targeting toward cancer cells. The chitosan thin film was very stable under neutral conditions and could effectively prevent drug leakage, but was sensitive to both pH and GSH stimulations to reach rapid drug release. Thus, drug release could be triggered by changes in such factors that are common to cancer cells. However, complete and accelerated release could only be realized when triggered simultaneously by both acidic pH and GSH. Moreover, tests with HepG-2 cells confirmed that folate-receptor mediated endocytosis successfully enhanced the cellular uptake of the nanoparticle and antitumor activity toward cancer cells. It is expected that this surface chemical modification strategy promises a powerful approach constructing smart drug delivery systems for efficient and safe chemotherapy.

Original languageEnglish (US)
Pages (from-to)1090-1099
Number of pages10
JournalInternational Journal of Biological Macromolecules
Volume122
DOIs
StatePublished - Feb 1 2019
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 31471659 , 21636003 and 21672065 ) and the Fundamental Research Funds for the Central Universities (No. 22221818014 ). Authors thank the support from Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM).

Publisher Copyright:
© 2018 Elsevier B.V.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • Mesoporous silica nanoparticles
  • Target drug delivery
  • pH/GSH dual-responsive

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