A safety assessment of branched chain saturated alcohols when used as fragrance ingredients

D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J. M. Hanifin, A. E. Rogers, J. H. Saurat, I. G. Sipes, H. Tagami

    Research output: Contribution to journalReview article

    33 Citations (Scopus)

    Abstract

    The Branched Chain Saturated Alcohol (BCSA) group of fragrance ingredients was evaluated for safety. In humans, no evidence of skin irritation was found at concentrations of 2-10%. Undiluted, 11 materials evaluated caused moderate to severe eye irritation. As current end product use levels are between 0.001% and 1.7%, eye irritation is not a concern. The materials have no or low sensitizing potential. For individuals who are already sensitized, an elicitation reaction is possible. Due to lack of UVA/UVB light-absorbing structures, and review of phototoxic/photoallergy data, the BCSA are not expected to elicit phototoxicity or photoallergy. The 15 materials tested have a low order of acute toxicity. Following repeated application, seven BCSA tested were of low systemic toxicity. Studies performed on eight BCSA and three metabolites show no in vivo or in vitro genotoxicity. A valid carcinogenicity study showed that 2-ethyl-1-hexanol is a weak inducer of liver tumors in female mice, however, the relevance of this effect and mode of action to humans is still a matter of debate. The Panel is of the opinion that there are no safety concerns regarding BCSA under the present levels of use and exposure.

    Original languageEnglish (US)
    JournalFood and Chemical Toxicology
    Volume48
    Issue numberSUPPL. 4
    DOIs
    StatePublished - Jul 1 2010

    Fingerprint

    Fragrances
    safety assessment
    ingredients
    alcohols
    odors
    Alcohols
    Safety
    Photoallergic Dermatitis
    eye irritation
    Toxicity
    phototoxicity
    Phototoxic Dermatitis
    skin irritation
    carcinogenicity
    liver neoplasms
    genotoxicity
    acute toxicity
    Metabolites
    Liver
    ultraviolet radiation

    Keywords

    • Branched chain saturated alcohols
    • Fragrance ingredients
    • Review
    • Safety

    Cite this

    A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. / Belsito, D.; Bickers, D.; Bruze, M.; Calow, P.; Greim, H.; Hanifin, J. M.; Rogers, A. E.; Saurat, J. H.; Sipes, I. G.; Tagami, H.

    In: Food and Chemical Toxicology, Vol. 48, No. SUPPL. 4, 01.07.2010.

    Research output: Contribution to journalReview article

    Belsito, D, Bickers, D, Bruze, M, Calow, P, Greim, H, Hanifin, JM, Rogers, AE, Saurat, JH, Sipes, IG & Tagami, H 2010, 'A safety assessment of branched chain saturated alcohols when used as fragrance ingredients', Food and Chemical Toxicology, vol. 48, no. SUPPL. 4. https://doi.org/10.1016/j.fct.2010.05.046
    Belsito, D. ; Bickers, D. ; Bruze, M. ; Calow, P. ; Greim, H. ; Hanifin, J. M. ; Rogers, A. E. ; Saurat, J. H. ; Sipes, I. G. ; Tagami, H. / A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. In: Food and Chemical Toxicology. 2010 ; Vol. 48, No. SUPPL. 4.
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