A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells

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Abstract

The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4+ T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4+ T-cells.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalAgents and Actions Supplements
Volume49
StatePublished - Dec 12 1997

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