A role for flavin monooxygenase-like enzymes in auxin biosynthesis

Y. Zhao, S. K. Christensen, C. Fankhauser, J. R. Cashman, J. D. Cohen, D. Weigel, J. Chory

Research output: Contribution to journalArticlepeer-review

940 Scopus citations


Although auxin is known to regulate many processes in plant development and has been studied for over a century, the mechanisms whereby plants produce it have remained elusive. Here we report the characterization of a dominant Arabidopsis mutant, yucca, which contains elevated levels of free auxin. YUCCA encodes a flavin monooxygenase-like enzyme and belongs to a family that includes at least nine other homologous Arabidopsis genes, a subset of which appears to have redundant functions. Results from tryptophan analog feeding experiments and biochemical assays indicate that YUCCA catalyzes hydroxylation of the amino group of tryptamine, a rate-limiting step in tryptophan-dependent auxin biosynthesis.

Original languageEnglish (US)
Pages (from-to)306-309
Number of pages4
Issue number5502
StatePublished - Jan 12 2001


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