Abstract
Allele sharing method or trait-model-free approach is a robust technique for linkage detection. In allele sharing method, the association between the joint inheritance of the trait and a set of markers in pedigrees is studied without modelling the trait. This paper aims at an efficient implementation of allele-sharing method for binary trait in multi-generation pedigrees that includes construction of a robust identity by descent measure, and the use of a computationally efficient testing procedure to test for linkage. Simulation studies demonstrate that the proposed method performs well on extended pedigrees and appears to outperform the existing allele-sharing approaches on moderate size pedigrees.
Original language | English (US) |
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Pages (from-to) | 405-424 |
Number of pages | 20 |
Journal | Sankhya: The Indian Journal of Statistics |
Volume | 69 |
Issue number | 3 |
State | Published - Dec 1 2007 |
Keywords
- Identity by descent
- Permutation test
- Robust linkage analysis