A RhoA-Derived peptide inhibits human immunodeficiency Virus-1 entry In Vitro

Maciej Maselko, Casey Ward, Manoj Pastey

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalCurrent HIV research
Volume9
Issue number1
DOIs
StatePublished - Feb 22 2011

Keywords

  • Antiviral
  • HIV-1
  • Peptides
  • RhoA

Fingerprint Dive into the research topics of 'A RhoA-Derived peptide inhibits human immunodeficiency Virus-1 entry In Vitro'. Together they form a unique fingerprint.

Cite this