A revised diagnostic classification of canine glioma: Towards validation of the canine glioma patient as a naturally occurring preclinical model for human glioma

Jennifer W. Koehler, Andrew D. Miller, C. Ryan Miller, Brian Porter, Kenneth Aldape, Jessica Beck, Daniel Brat, Ingrid Cornax, Kara Corps, Chad Frank, Caterina Giannini, Craig Horbinski, Jason T. Huse, M. Gerard O'Sullivan, Daniel R. Rissi, R. Mark Simpson, Kevin Woolard, Joanna H. Shih, Christina Mazcko, Mark R. GilbertAmy K. LeBlanc

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The National Cancer Institute-led multidisciplinary Comparative Brain Tumor Consortium (CBTC) convened a glioma pathology board, comprising both veterinarian and physician neuropathologists, and conducted a comprehensive review of 193 cases of canine glioma. The immediate goal was to improve existing glioma classification methods through creation of a histologic atlas of features, thus yielding greater harmonization of phenotypic characterization. The long-term goal was to support future incorporation of clinical outcomes and genomic data into proposed simplified diagnostic schema, so as to further bridge the worlds of veterinary and physician neuropathology and strengthen validity of the dog as a naturally occurring, translationally relevant animal model of human glioma. All cases were morphologically reclassified according to a new schema devised by the entire board, yielding a majority opinion diagnosis of astrocytoma (43, 22.3%), 19 of which were low-grade and 24 high-grade, and oligodendroglioma (134, 69.4%), 35 of which were low-grade and 99 were high-grade. Sixteen cases (8.3%) could not be classified as oligodendroglioma or astrocytoma based on morphology alone and were designated as undefined gliomas. The simplified classification scheme proposed herein provides a tractable means for future addition of molecular data, and also serves to highlight histologic similarities and differences between human and canine glioma.

Original languageEnglish (US)
Pages (from-to)1039-1054
Number of pages16
JournalJournal of neuropathology and experimental neurology
Volume77
Issue number11
DOIs
StatePublished - 2018

Bibliographical note

Funding Information:
This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH), NCI, Center for Cancer Re-search. Jessica Beck and Kara Corps are supported in part by the NIH Comparative Biomedical Scientist Training Program, in partnership with Purdue University (Jessica Beck) and North Carolina State University (Kara Corps). The results and interpretations do not reflect the views of the US Government.

Funding Information:
The authors thank Joseph Meyer and Jen Patterson for assistance with figures and photomicrographs, respectively. The authors also thank John H Rossmeisl, Sarah Moore, Amy Durham, Rebecca Packer, Amy Hodshon, Jonathan Levine, Elizabeth Boudreau, G. Elizabeth Pluhar, Peter Dickinson, Jonathan Wood, and R. Timothy Bentley for assistance with submission of case material, and thank Cynthia Hutchinson and Lisa Parsons to Shelley Hoover for assistance with staining, slide scanning, and image management. The UNC Translational Pathology Laboratory is supported by the NCI (P30CA016086) and University Cancer Research Fund (UCRF).

Keywords

  • Canine
  • Comparative
  • Glioma

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