A review of therapeutic ablation modalities

Ashish Singal, John R. Ballard, Eric N. Rudie, Erik N.K. Cressman, Paul A. Iaizzo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Understanding basic science and technical aspects is essential for scientists and engineers to develop and enhance ablative modalities, and for clinicians to effectively apply therapeutic ablative techniques. An overview of ablative modalities, anatomical locations, and indications for which ablations are performed is presented. Specifically, basic concepts, parameter selection, and underlying biophysics of tissue injury of five currently used therapeutic ablative modalities are reviewed: radiofrequency ablation (RFA), cryoablation (CRA), microwave ablation (MWA), high-intensity focused ultrasound (HIFU), and chemical ablation (CHA) (ablative agents: acetic acid, ethanol, hypertonic sodium chloride, and urea). Each ablative modality could be refined for expanding applications, either independently or in combination, for future therapeutic use.

Original languageEnglish (US)
Article number040801
JournalJournal of Medical Devices, Transactions of the ASME
Issue number4
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 by ASME.


  • Chemical ablation
  • Cryoablation
  • High-intensity focused ultrasound
  • Microwave
  • Radiofrequency


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