A review of the scientific rigor, reproducibility, and transparency studies conducted by the ABRF research groups

Sheenah M. Mische, Nancy C. Fisher, Susan M. Meyn, Katia Sol Church, Rebecca L. Hegstad-Davies, Frances Weis-Garcia, Marie Adams, John M. Ashton, Kym M. Delventhal, Julie A. Dragon, Laura Holmes, Pratik Jagtap, Kristopher E. Kubow, Christopher E. Mason, Magnus Palmblad, Brian C. Searle, Christoph W. Turck, Kevin L. Knudtson

Research output: Contribution to journalReview article

Abstract

Shared research resource facilities, also known as core laboratories (Cores), are responsible for generating a significant and growing portion of the research data in academic biomedical research institutions. Cores represent a central repository for institutional knowledge management, with deep expertise in the strengths and limitations of technology and its applications. They inherently support transparency and scientific reproduc-ibility by protecting against cognitive bias in research design and data analysis, and they have institutional responsibility for the conduct of research (research ethics, regulatory compliance, and financial accountability) performed in their Cores. The Association of Biomolecular Resource Facilities (ABRF) is a FASEB-member scientific society whose members are scientists and administrators that manage or support Cores. The ABRF Research Groups (RGs), representing expertise for an array of cutting-edge and established technology platforms, perform multicenter research studies to determine and communicate best practices and community-based standards. This review provides a summary of the contributions of the ABRF RGs to promote scientific rigor and reproducibility in Cores from the published literature, ABRF meetings, and ABRF RGs communications.

Original languageEnglish (US)
Pages (from-to)11-26
Number of pages16
JournalJournal of Biomolecular Techniques
Volume31
Issue number1
DOIs
StatePublished - Apr 2020

Keywords

  • Collaborative research
  • Community based standards
  • Core laboratories
  • Multicenter research studies
  • Shared resource

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    Mische, S. M., Fisher, N. C., Meyn, S. M., Church, K. S., Hegstad-Davies, R. L., Weis-Garcia, F., Adams, M., Ashton, J. M., Delventhal, K. M., Dragon, J. A., Holmes, L., Jagtap, P., Kubow, K. E., Mason, C. E., Palmblad, M., Searle, B. C., Turck, C. W., & Knudtson, K. L. (2020). A review of the scientific rigor, reproducibility, and transparency studies conducted by the ABRF research groups. Journal of Biomolecular Techniques, 31(1), 11-26. https://doi.org/10.7171/jbt.20-3101-003