A review of the scientific rigor, reproducibility, and transparency studies conducted by the ABRF research groups

Sheenah M. Mische, Nancy C. Fisher, Susan M. Meyn, Katia Sol Church, Rebecca L. Hegstad-Davies, Frances Weis-Garcia, Marie Adams, John M. Ashton, Kym M. Delventhal, Julie A. Dragon, Laura Holmes, Pratik Jagtap, Kristopher E. Kubow, Christopher E. Mason, Magnus Palmblad, Brian C. Searle, Christoph W. Turck, Kevin L. Knudtson

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Shared research resource facilities, also known as core laboratories (Cores), are responsible for generating a significant and growing portion of the research data in academic biomedical research institutions. Cores represent a central repository for institutional knowledge management, with deep expertise in the strengths and limitations of technology and its applications. They inherently support transparency and scientific reproduc-ibility by protecting against cognitive bias in research design and data analysis, and they have institutional responsibility for the conduct of research (research ethics, regulatory compliance, and financial accountability) performed in their Cores. The Association of Biomolecular Resource Facilities (ABRF) is a FASEB-member scientific society whose members are scientists and administrators that manage or support Cores. The ABRF Research Groups (RGs), representing expertise for an array of cutting-edge and established technology platforms, perform multicenter research studies to determine and communicate best practices and community-based standards. This review provides a summary of the contributions of the ABRF RGs to promote scientific rigor and reproducibility in Cores from the published literature, ABRF meetings, and ABRF RGs communications.

Original languageEnglish (US)
Pages (from-to)11-26
Number of pages16
JournalJournal of Biomolecular Techniques
Issue number1
StatePublished - Apr 2020

Bibliographical note

Funding Information:
The authors thank the members of the current ABRF Research Groups (see Appendix) and all the ABRF members who have served on the ABRF Research Groups for their time, scientific expertise, and body of published literature dedicated to advancing technology over the last 30 yr. Sincere thanks to Ron Niece and George Grills, who offered insightful and critical contributions to this manuscript. N.C.F. is supported by P30 CA016086 Cancer Center Core Support Grant to the UNC Lineberger Comprehensive Cancer Center. K.L.K. is supported in part by the National Cancer Institute of the U.S. National Institutes of Health (NIH) under award number P30 CA086862. S.M.M. is supported in part by the National Cancer Institute of the NIH Cancer Center Grant P30 CA068485. S.M.M. is supported by P30 CA016087 Cancer Center Core Support Grant at the New York University Langone Laura and Isaac Perlmutter Comprehensive Cancer Center. F.W.-G. is supported by P30 CA008748 Cancer Center Core Support Grant at the Memorial Sloan Kettering Cancer Center. K.S.C. is supported in part by the National Institute of General Medical Sciences of the NIH IDeA program under award numbers P30 GM114736 and P20 GM103446. The authors declare no conflicts of interest.

Publisher Copyright:
© 2020 ABRF.


  • Collaborative research
  • Community based standards
  • Core laboratories
  • Multicenter research studies
  • Shared resource


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