A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon

Cameron Crowell; Ziwen Zhu; Yingxiang Li; Maria L. Varela; Quinn Ostrom; Patrick J. Cimino; Sohil H. Patel; Suzanne J. Baker; Chetan Bettegowda; Houtan Noushmehr; Claudia L. Kleinman; Laura Canty; Gustavo Alencastro Veiga Cruzeiro; Anandani Nellan; Oren Becher; Tom B. Davidson; Dolores Hambardzumyan; Adam Green; Robert Thorne; Kelli Wilson; Brett Theeler; Jason Gregory; Peter Mathen; Nadia Biassou; Sheila McThenia; Craig Erker; Robert Galvin; Ariane Soldatos; Pedro R. Lowenstein; Maria G. Castro; Sadhana Jackson

doi:10.1038/s41698-025-01070-w

A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon

Cameron Crowell
, Ziwen Zhu
, Yingxiang Li
, Maria L. Varela
, Quinn Ostrom
, Patrick J. Cimino
, Sohil H. Patel
, Suzanne J. Baker
, Chetan Bettegowda
, Houtan Noushmehr
, Claudia L. Kleinman
, Laura Canty
, Gustavo Alencastro Veiga Cruzeiro
, Anandani Nellan
, Oren Becher
, Tom B. Davidson
, Dolores Hambardzumyan
, Adam Green
, Robert Thorne
, Kelli Wilson

Brett Theeler, Jason Gregory, Peter Mathen, Nadia Biassou, Sheila McThenia, Craig Erker, Robert Galvin, Ariane Soldatos, Pedro R. Lowenstein, Maria G. Castro, Sadhana Jackson

Pediatric Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Diffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood. Combining previous published studies with findings from the 2024 NIH G34-mutant symposium aid in summarizing translational and clinical updates on disease development, cellular repair processes, and the immune microenvironment. This collective work is meant to outline opportunities for treatment and prolonged survival.

Original language	English (US)
Article number	283
Journal	npj Precision Oncology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41698-025-01070-w
State	Published - Dec 2025

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Publisher Copyright:
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2025.

PubMed: MeSH publication types

Journal Article
Review

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10.1038/s41698-025-01070-w

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Crowell, C., Zhu, Z., Li, Y., Varela, M. L., Ostrom, Q., Cimino, P. J., Patel, S. H., Baker, S. J., Bettegowda, C., Noushmehr, H., Kleinman, C. L., Canty, L., Cruzeiro, G. A. V., Nellan, A., Becher, O., Davidson, T. B., Hambardzumyan, D., Green, A., Thorne, R., ... Jackson, S. (2025). A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon. npj Precision Oncology, 9(1), Article 283. https://doi.org/10.1038/s41698-025-01070-w

Crowell, C, Zhu, Z, Li, Y, Varela, ML, Ostrom, Q, Cimino, PJ, Patel, SH, Baker, SJ, Bettegowda, C, Noushmehr, H, Kleinman, CL, Canty, L, Cruzeiro, GAV, Nellan, A, Becher, O, Davidson, TB, Hambardzumyan, D, Green, A, Thorne, R, Wilson, K, Theeler, B, Gregory, J, Mathen, P, Biassou, N, McThenia, S, Erker, C, Galvin, R, Soldatos, A, Lowenstein, PR, Castro, MG & Jackson, S 2025, 'A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon', npj Precision Oncology, vol. 9, no. 1, 283. https://doi.org/10.1038/s41698-025-01070-w

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title = "A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon",

abstract = "Diffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood. Combining previous published studies with findings from the 2024 NIH G34-mutant symposium aid in summarizing translational and clinical updates on disease development, cellular repair processes, and the immune microenvironment. This collective work is meant to outline opportunities for treatment and prolonged survival.",

author = "Cameron Crowell and Ziwen Zhu and Yingxiang Li and Varela, \{Maria L.\} and Quinn Ostrom and Cimino, \{Patrick J.\} and Patel, \{Sohil H.\} and Baker, \{Suzanne J.\} and Chetan Bettegowda and Houtan Noushmehr and Kleinman, \{Claudia L.\} and Laura Canty and Cruzeiro, \{Gustavo Alencastro Veiga\} and Anandani Nellan and Oren Becher and Davidson, \{Tom B.\} and Dolores Hambardzumyan and Adam Green and Robert Thorne and Kelli Wilson and Brett Theeler and Jason Gregory and Peter Mathen and Nadia Biassou and Sheila McThenia and Craig Erker and Robert Galvin and Ariane Soldatos and Lowenstein, \{Pedro R.\} and Castro, \{Maria G.\} and Sadhana Jackson",

note = "Publisher Copyright: {\textcopyright} This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2025.",

year = "2025",

month = dec,

doi = "10.1038/s41698-025-01070-w",

language = "English (US)",

volume = "9",

journal = "npj Precision Oncology",

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AU - Varela, Maria L.

AU - Ostrom, Quinn

AU - Cimino, Patrick J.

AU - Patel, Sohil H.

AU - Baker, Suzanne J.

AU - Bettegowda, Chetan

AU - Noushmehr, Houtan

AU - Kleinman, Claudia L.

AU - Canty, Laura

AU - Cruzeiro, Gustavo Alencastro Veiga

AU - Nellan, Anandani

AU - Becher, Oren

AU - Davidson, Tom B.

AU - Hambardzumyan, Dolores

AU - Green, Adam

AU - Thorne, Robert

AU - Wilson, Kelli

AU - Theeler, Brett

AU - Gregory, Jason

AU - Mathen, Peter

AU - Biassou, Nadia

AU - McThenia, Sheila

AU - Erker, Craig

AU - Galvin, Robert

AU - Soldatos, Ariane

AU - Lowenstein, Pedro R.

AU - Castro, Maria G.

AU - Jackson, Sadhana

PY - 2025/12

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AB - Diffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood. Combining previous published studies with findings from the 2024 NIH G34-mutant symposium aid in summarizing translational and clinical updates on disease development, cellular repair processes, and the immune microenvironment. This collective work is meant to outline opportunities for treatment and prolonged survival.

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ER -

A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon

Abstract

Bibliographical note

PubMed: MeSH publication types

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