A reinvigorated era of bacterial secondary metabolite discovery

Ashley M. Sidebottom, Erin E. Carlson

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Secondary metabolite discovery from bacteria has become increasingly successful in the last decade due to the advancement of integrated genetic-based, spectrometric-based and informatics-based techniques. Microbes and their unique metabolic outputs have been widely studied since the beginning of modern medicine however, it is well known that the current repertoire of secondary metabolites, or more commonly natural products, is incomplete and the understanding of natural product-mediated intracellular dialog is in its infancy. Here, we highlight the present state of bacterial metabolomics including compound discovery approaches and new strategies for probing the role of these molecules within communication networks.

Original languageEnglish (US)
Pages (from-to)104-111
Number of pages8
JournalCurrent opinion in chemical biology
Volume24
DOIs
StatePublished - Feb 1 2015

Bibliographical note

Funding Information:
This work was supported by an NSF CAREER Award, a Pew Biomedical Scholar Award (E.E.C.), a Sloan Research Fellow Award (E.E.C.), and the Research Corporation for Science Advancement (Cottrell Scholar Award; E.E.C.).

Publisher Copyright:
© 2014 Elsevier Ltd.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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