A reduced order model for spatiotemporal dynamics and control of cardiac alternans

Xiaopeng Zhao, Alena Talkachova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Sudden cardiac arrest, caused primarily by ventricular fibrillation, is one of the leading causes of mortality in the Western world. There is a compelling need for risk stratification to identify patients at risk for sudden cardiac arrest. Cardiac alternans, a recognized harbinger of sudden cardiac arrest, manifests as a beat-to-beat alternation in action potential duration (cellular level) or in electrocardiogram morphology (whole heart level). Although much progress has been made to understand the mechanisms of alternans, predicting and control of alternans, especially at the heart level, remain great challenges. Current approaches to predict cardiac alternans based on restitution properties of the heart are either too simple to be valid or too complex to be useful. In this work, we developed a reduced order model from the amplitude equation to investigate dynamics and control of alternans in cardiac fiber, i.e. beyond single cell level. Detailed bifurcation and stability analyses were carried out to illustrate complex spatiotemporal patterns of alternans and the limitations in feedback control due to spatial effect.

Original languageEnglish (US)
Title of host publicationAdvances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791851890
DOIs
StatePublished - Jan 1 2018
EventASME 2018 Dynamic Systems and Control Conference, DSCC 2018 - Atlanta, United States
Duration: Sep 30 2018Oct 3 2018

Publication series

NameASME 2018 Dynamic Systems and Control Conference, DSCC 2018
Volume1

Other

OtherASME 2018 Dynamic Systems and Control Conference, DSCC 2018
CountryUnited States
CityAtlanta
Period9/30/1810/3/18

Fingerprint

Bioelectric potentials
Electrocardiography
Feedback control
Fibers

Cite this

Zhao, X., & Talkachova, A. (2018). A reduced order model for spatiotemporal dynamics and control of cardiac alternans. In Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare (ASME 2018 Dynamic Systems and Control Conference, DSCC 2018; Vol. 1). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DSCC2018-9071

A reduced order model for spatiotemporal dynamics and control of cardiac alternans. / Zhao, Xiaopeng; Talkachova, Alena.

Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare. American Society of Mechanical Engineers (ASME), 2018. (ASME 2018 Dynamic Systems and Control Conference, DSCC 2018; Vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhao, X & Talkachova, A 2018, A reduced order model for spatiotemporal dynamics and control of cardiac alternans. in Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare. ASME 2018 Dynamic Systems and Control Conference, DSCC 2018, vol. 1, American Society of Mechanical Engineers (ASME), ASME 2018 Dynamic Systems and Control Conference, DSCC 2018, Atlanta, United States, 9/30/18. https://doi.org/10.1115/DSCC2018-9071
Zhao X, Talkachova A. A reduced order model for spatiotemporal dynamics and control of cardiac alternans. In Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare. American Society of Mechanical Engineers (ASME). 2018. (ASME 2018 Dynamic Systems and Control Conference, DSCC 2018). https://doi.org/10.1115/DSCC2018-9071
Zhao, Xiaopeng ; Talkachova, Alena. / A reduced order model for spatiotemporal dynamics and control of cardiac alternans. Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare. American Society of Mechanical Engineers (ASME), 2018. (ASME 2018 Dynamic Systems and Control Conference, DSCC 2018).
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