A reanalysis of the stanton et al. pleural sarcoma data

Gary W. Oehlert

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


An analysis of the Stanton et al. (1981, J. Natl. Cancer Inst. 67, 965-975) data reconfirms number of index particles as the primary dimensional predictor of tumor incidence. Fitting separate intercepts and/or slopes to each mineral type results in substantial significant improvement in fit, indicating the importance of mineral type. This contrasts with the "Stanton hypothesis," which states that dimensional properties alone determine carcinogenesis. Log mean aspect ratio is not as good a predictor of tumor incidence as the number of index particles; among those samples that did not have index particles, log mean aspect ratio is not a significant predictor of tumor incidence.

Original languageEnglish (US)
Pages (from-to)194-205
Number of pages12
JournalEnvironmental Research
Issue number2
StatePublished - Apr 1991
Externally publishedYes


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