A randomized study of yoga therapy for the prevention of recurrent reflex vasovagal syncope

Jayaprakash Shenthar, Ritesh Singh Gangwar, Bharatraj Banavalikar, David G. Benditt, Dhanunjaya Lakkireddy, Deepak Padmanabhan

Research output: Contribution to journalArticlepeer-review

Abstract

AIMS: Vasovagal syncope (VVS) is a common cardiovascular dysautonomic disorder that significantly impacts health and quality of life (QoL). Yoga has been shown to have a positive influence on cardiovascular autonomics. This study assessed the effectiveness of yoga therapy on the recurrence of VVS and QoL.

METHODS AND RESULTS: We randomized subjects with recurrent reflex VVS (>3 episodes in the past 1 year) and positive head-up tilt test to guideline-directed therapy (Group 1) or yoga therapy (Group 2). Patients in Group 1 were advised guideline-directed treatment and Group 2 was taught yoga by a certified instructor. The primary endpoint was VVS recurrences and QoL. Between June 2015 and February 2017, 97 highly symptomatic VVS patients were randomized (Group 1: 47 and Group 2: 50). The mean age was 33.1 ± 16.6 years, male:female of 40:57, symptom duration of 17.1 ± 20.7 months, with a mean of 6.4 ± 6.1 syncope episodes. Over a follow-up of 14.3 ± 2.1 months Group 2 had significantly lower syncope burden compared with Group 1 at 3 (0.8 ± 0.9 vs. 1.8 ± 1.4, P < 0.001), 6 (1.0 ± 1.2 vs. 3.4 ± 3.0, P < 0.001), and at 12 months (1.1 ± 0.8 vs. 3.8 ± 3.2, P < 0.001). The Syncope functional score questionnaire was significantly lower in Group 2 compared with Group 1 at 3 (31.4 ± 7.2 vs. 64.1 ± 11.5, P < 0.001), 6 (26.4 ± 6.3 vs. 61.4 ± 10.7, P < 0.001), and 12 months (22.2 ± 4.7 vs. 68.3 ± 11.4, P < 0.001).

CONCLUSION: For patients with recurrent VVS, guided yoga therapy is superior to conventional therapy in reducing symptom burden and improving QoL.

Original languageEnglish (US)
Pages (from-to)1479-1486
Number of pages8
JournalEuropace
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2021

Bibliographical note

Publisher Copyright:
© 2021 Published on behalf of the European Society of Cardiology. All rights reserved.

Keywords

  • Reflex syncope
  • Syncope
  • Vasovagal syncope
  • Yoga therapy
  • Reflex
  • Humans
  • Middle Aged
  • Syncope, Vasovagal/diagnosis
  • Male
  • Young Adult
  • Adolescent
  • Quality of Life
  • Adult
  • Female
  • Yoga
  • Tilt-Table Test

PubMed: MeSH publication types

  • Journal Article
  • Randomized Controlled Trial

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