Objective: It is unclear if vitamin D supplementation improves central blood pressure or arterial stiffness in Native American (NA) women. Methods: Healthy postmenopausal NA women were randomized to receive 400 IU or 2500 IU of vitamin D for 6 months. Central systolic blood pressure (cSBP), central pulse pressure (cPP) and aortic augmentation index (AIx) were estimated by tonometry at baseline and after 6 months. Results: Study volunteers (n=98) were 61 (7.3) years old. 25(OH)D was 26.4 (11.0) ng/mL. 25(OH)D was similar between the two treatment groups (p=0.291), as were baseline cSBP, cPP, and CVD risk factors (all p>0.1). Treatment with 2500 IU of daily vitamin D3 did not affect cSBP, cPP, or AIx (all p>0.1) compared to 400 IU daily. Conclusions: Despite low serum 25(OH)D at baseline, 6 months of vitamin D supplementation did not improve central blood pressure parameters or arterial stiffness in NA women. Clinical trials. gov identifier: NCT01490333.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jun 1 2015|
Bibliographical noteFunding Information:
Supported by NIMHD Comprehensive Centers of Excellence, P60/R01: MD 003428-01 and was supported in part by a T32 HL 07936 from the NHLBI.
© 2015 Elsevier Ireland Ltd.
- Arterial stiffness
- Cardiovascular disease risk
- Central blood pressure
- Vitamin D