A randomized controlled trial of the effects of vitamin D supplementation on arterial stiffness and aortic blood pressure in Native American women

Adam D. Gepner, Irina V. Haller, Diane C. Krueger, Claudia E. Korcarz, Neil Binkley, James H. Stein

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: It is unclear if vitamin D supplementation improves central blood pressure or arterial stiffness in Native American (NA) women. Methods: Healthy postmenopausal NA women were randomized to receive 400 IU or 2500 IU of vitamin D for 6 months. Central systolic blood pressure (cSBP), central pulse pressure (cPP) and aortic augmentation index (AIx) were estimated by tonometry at baseline and after 6 months. Results: Study volunteers (n=98) were 61 (7.3) years old. 25(OH)D was 26.4 (11.0) ng/mL. 25(OH)D was similar between the two treatment groups (p=0.291), as were baseline cSBP, cPP, and CVD risk factors (all p>0.1). Treatment with 2500 IU of daily vitamin D3 did not affect cSBP, cPP, or AIx (all p>0.1) compared to 400 IU daily. Conclusions: Despite low serum 25(OH)D at baseline, 6 months of vitamin D supplementation did not improve central blood pressure parameters or arterial stiffness in NA women. Clinical trials. gov identifier: NCT01490333.

Original languageEnglish (US)
Pages (from-to)526-528
Number of pages3
JournalAtherosclerosis
Volume240
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • Arterial stiffness
  • Cardiovascular disease risk
  • Central blood pressure
  • Vitamin D

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