A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression

Jennifer A. Linde, Gregory E. Simon, Evette J. Ludman, Laura E. Ichikawa, Belinda H. Operskalski, David Arterburn, Paul Rohde, Emily A. Finch, Robert W. Jeffery

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Background: Obesity is associated with clinical depression among women. However, depressed women are often excluded from weight loss trials. Purpose: This study examined treatment outcomes among women with comorbid obesity and depression. Methods: Two hundred three (203) women were randomized to behavioral weight loss (n∈=∈102) or behavioral weight loss combined with cognitive-behavioral depression management (n∈=∈101). Results: Average participant age was 52 years; mean baseline body mass index was 39 kg/m 2. Mean Patient Health Questionnaire and Hopkins Symptom Checklist (SCL-20) scores indicated moderate to severe baseline depression. Weight loss and SCL-20 changes did not differ between groups at 6 or 12 months in intent-to-treat analyses (p∈=∈0.26 and 0.55 for weight, p∈=∈0.70 and 0.25 for depressive symptoms). Conclusions: Depressed obese women lost weight and demonstrated improved mood in both treatment programs. Future weight loss trials are encouraged to enroll depressed women.

Original languageEnglish (US)
Pages (from-to)119-130
Number of pages12
JournalAnnals of Behavioral Medicine
Volume41
Issue number1
DOIs
StatePublished - Feb 2011

Bibliographical note

Funding Information:
Acknowledgments This study was funded by National Institutes of Health Grant R01MH068127 (G. E. Simon, PI); ClinicalTrials.gov identifier: NCT00169273, “Epidemiology and Care of Comorbid Obesity and Depression.” Conflict of Interest Statement The authors have no conflicts of interest to disclose.

Keywords

  • Comorbidity
  • Depression
  • Intervention
  • Obesity
  • Women

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