A quantitative structure-activity relationship study of N-alkylnorketobemidones and triazinones using structural information content

A newly formulated information-theoretic topological index, structural information content (SIC), was applied to quantitative structure-activity relationship (QSAR) studies with N-alkylnorketobemidones and triazinones. Results show that SIC encodes sufficient molecular structural information to correlate significantly with the physical as well as biological properties of both the groups of congeners.