A quantitative structure-activity relationship study of N-alkylnorketobemidones and triazinones using structural information content

S. K. Ray; S. C. Basak; C. Raychaudhury; A. B. Roy; J. J. Ghosh

A quantitative structure-activity relationship study of N-alkylnorketobemidones and triazinones using structural information content

S. K. Ray, S. C. Basak, C. Raychaudhury, A. B. Roy, J. J. Ghosh

Natural Resources Research Institute

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Abstract

A newly formulated information-theoretic topological index, structural information content (SIC), was applied to quantitative structure-activity relationship (QSAR) studies with N-alkylnorketobemidones and triazinones. Results show that SIC encodes sufficient molecular structural information to correlate significantly with the physical as well as biological properties of both the groups of congeners.

Original language	English (US)
Pages (from-to)	322-325
Number of pages	4
Journal	Arzneimittel-Forschung/Drug Research
Volume	32
Issue number	4
State	Published - Jun 11 1982

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title = "A quantitative structure-activity relationship study of N-alkylnorketobemidones and triazinones using structural information content",

abstract = "A newly formulated information-theoretic topological index, structural information content (SIC), was applied to quantitative structure-activity relationship (QSAR) studies with N-alkylnorketobemidones and triazinones. Results show that SIC encodes sufficient molecular structural information to correlate significantly with the physical as well as biological properties of both the groups of congeners.",

author = "Ray, {S. K.} and Basak, {S. C.} and C. Raychaudhury and Roy, {A. B.} and Ghosh, {J. J.}",

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T1 - A quantitative structure-activity relationship study of N-alkylnorketobemidones and triazinones using structural information content

AU - Ray, S. K.

AU - Basak, S. C.

AU - Raychaudhury, C.

AU - Roy, A. B.

AU - Ghosh, J. J.

PY - 1982/6/11

Y1 - 1982/6/11

N2 - A newly formulated information-theoretic topological index, structural information content (SIC), was applied to quantitative structure-activity relationship (QSAR) studies with N-alkylnorketobemidones and triazinones. Results show that SIC encodes sufficient molecular structural information to correlate significantly with the physical as well as biological properties of both the groups of congeners.

AB - A newly formulated information-theoretic topological index, structural information content (SIC), was applied to quantitative structure-activity relationship (QSAR) studies with N-alkylnorketobemidones and triazinones. Results show that SIC encodes sufficient molecular structural information to correlate significantly with the physical as well as biological properties of both the groups of congeners.

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C2 - 6285936

AN - SCOPUS:0020035735

SN - 2194-9379

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JO - Drug Research

JF - Drug Research

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ER -

A quantitative structure-activity relationship study of N-alkylnorketobemidones and triazinones using structural information content

Abstract

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