A quantitative analysis on the thermal properties of phosphate buffered saline with glycerol at subzero temperatures

Jeung Hwan Choi; John C. Bischof

doi:10.1016/j.ijheatmasstransfer.2007.04.041

A quantitative analysis on the thermal properties of phosphate buffered saline with glycerol at subzero temperatures

Jeung Hwan Choi
, John C. Bischof

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

This study reports the first comprehensive data on the effects of glycerol, a widely used cryoprotective agent (CPA), on the thermal properties of Phosphate Buffered Saline at subzero and cryogenic (≤-40 °C) temperatures. A Differential Scanning Calorimeter was used to measure specific and latent heats. Thermal conductivity was determined using a thermistor probe technique. Results differed significantly from known water (ice) or glycerol values, and a simple weight averaging method between water and glycerol was found to over-predict thermal conductivity below -100 °C due to glass formation. This indicates the need for these newly measured thermal properties of CPA solutions particularly below -100 °C.

Original language	English (US)
Pages (from-to)	640-649
Number of pages	10
Journal	International Journal of Heat and Mass Transfer
Volume	51
Issue number	3-4
DOIs	https://doi.org/10.1016/j.ijheatmasstransfer.2007.04.041
State	Published - Feb 2008

Bibliographical note

Funding Information:
This work was supported by the United States National Science Foundation (NSF) under Grant No. CTS 0313934. The authors thank Dr. Willem F. Wolkers for a careful read of the manuscript.

Keywords

Glycerol
Phosphate buffered saline
Subzero
Thermal property

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10.1016/j.ijheatmasstransfer.2007.04.041

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title = "A quantitative analysis on the thermal properties of phosphate buffered saline with glycerol at subzero temperatures",

abstract = "This study reports the first comprehensive data on the effects of glycerol, a widely used cryoprotective agent (CPA), on the thermal properties of Phosphate Buffered Saline at subzero and cryogenic (≤-40 °C) temperatures. A Differential Scanning Calorimeter was used to measure specific and latent heats. Thermal conductivity was determined using a thermistor probe technique. Results differed significantly from known water (ice) or glycerol values, and a simple weight averaging method between water and glycerol was found to over-predict thermal conductivity below -100 °C due to glass formation. This indicates the need for these newly measured thermal properties of CPA solutions particularly below -100 °C.",

keywords = "Glycerol, Phosphate buffered saline, Subzero, Thermal property",

author = "Choi, \{Jeung Hwan\} and Bischof, \{John C.\}",

note = "Funding Information: This work was supported by the United States National Science Foundation (NSF) under Grant No. CTS 0313934. The authors thank Dr. Willem F. Wolkers for a careful read of the manuscript.",

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T1 - A quantitative analysis on the thermal properties of phosphate buffered saline with glycerol at subzero temperatures

AU - Choi, Jeung Hwan

AU - Bischof, John C.

N1 - Funding Information: This work was supported by the United States National Science Foundation (NSF) under Grant No. CTS 0313934. The authors thank Dr. Willem F. Wolkers for a careful read of the manuscript.

PY - 2008/2

Y1 - 2008/2

N2 - This study reports the first comprehensive data on the effects of glycerol, a widely used cryoprotective agent (CPA), on the thermal properties of Phosphate Buffered Saline at subzero and cryogenic (≤-40 °C) temperatures. A Differential Scanning Calorimeter was used to measure specific and latent heats. Thermal conductivity was determined using a thermistor probe technique. Results differed significantly from known water (ice) or glycerol values, and a simple weight averaging method between water and glycerol was found to over-predict thermal conductivity below -100 °C due to glass formation. This indicates the need for these newly measured thermal properties of CPA solutions particularly below -100 °C.

AB - This study reports the first comprehensive data on the effects of glycerol, a widely used cryoprotective agent (CPA), on the thermal properties of Phosphate Buffered Saline at subzero and cryogenic (≤-40 °C) temperatures. A Differential Scanning Calorimeter was used to measure specific and latent heats. Thermal conductivity was determined using a thermistor probe technique. Results differed significantly from known water (ice) or glycerol values, and a simple weight averaging method between water and glycerol was found to over-predict thermal conductivity below -100 °C due to glass formation. This indicates the need for these newly measured thermal properties of CPA solutions particularly below -100 °C.

KW - Glycerol

KW - Phosphate buffered saline

KW - Subzero

KW - Thermal property

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UR - https://www.scopus.com/pages/publications/37649020777#tab=citedBy

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DO - 10.1016/j.ijheatmasstransfer.2007.04.041

M3 - Article

AN - SCOPUS:37649020777

SN - 0017-9310

VL - 51

SP - 640

EP - 649

JO - International Journal of Heat and Mass Transfer

JF - International Journal of Heat and Mass Transfer

IS - 3-4

ER -

A quantitative analysis on the thermal properties of phosphate buffered saline with glycerol at subzero temperatures

Abstract

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Keywords

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