A quantitative analysis on the thermal properties of phosphate buffered saline with glycerol at subzero temperatures

Jeung Hwan Choi, John C. Bischof

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This study reports the first comprehensive data on the effects of glycerol, a widely used cryoprotective agent (CPA), on the thermal properties of Phosphate Buffered Saline at subzero and cryogenic (≤-40 °C) temperatures. A Differential Scanning Calorimeter was used to measure specific and latent heats. Thermal conductivity was determined using a thermistor probe technique. Results differed significantly from known water (ice) or glycerol values, and a simple weight averaging method between water and glycerol was found to over-predict thermal conductivity below -100 °C due to glass formation. This indicates the need for these newly measured thermal properties of CPA solutions particularly below -100 °C.

Original languageEnglish (US)
Pages (from-to)640-649
Number of pages10
JournalInternational Journal of Heat and Mass Transfer
Volume51
Issue number3-4
DOIs
StatePublished - Feb 1 2008

Keywords

  • Glycerol
  • Phosphate buffered saline
  • Subzero
  • Thermal property

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