Projects per year
Abstract
Chemical permeation enhancers (CPEs) represent a prevalent and safe strategy to enable noninvasive drug delivery across skin-like biological barriers such as the tympanic membrane (TM). While most existing CPEs interact strongly with the lipid bilayers in the stratum corneum to create defects as diffusion paths, their interactions with the delivery system, such as polymers forming a hydrogel, can compromise gelation, formulation stability, and drug diffusion. To overcome this challenge, differing interactions between CPEs and the hydrogel system are explored, especially those with sodium dodecyl sulfate (SDS), an ionic surfactant and a common CPE, and those with methyl laurate (ML), a nonionic counterpart with a similar length alkyl chain. Notably, the use of ML effectively decouples permeation enhancement from gelation, enabling sustained delivery across TMs to treat acute otitis media (AOM), which is not possible with the use of SDS. Ciprofloxacin and ML are shown to form a pseudo-surfactant that significantly boosts transtympanic permeation. The middle ear ciprofloxacin concentration is increased by 70-fold in vivo in a chinchilla AOM model, yielding superior efficacy and biocompatibility than the previous highest-performing formulation. Beyond improved efficacy and biocompatibility, this single-CPE formulation significantly accelerates its progression toward clinical deployment.
Original language | English (US) |
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Article number | 2400457 |
Journal | Advanced Healthcare Materials |
Volume | 13 |
Issue number | 22 |
DOIs | |
State | Published - Sep 1 2024 |
Bibliographical note
Publisher Copyright:© 2024 Wiley-VCH GmbH.
MRSEC Support
- Partial
PubMed: MeSH publication types
- Journal Article
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Dive into the research topics of 'A Pseudo‐Surfactant Chemical Permeation Enhancer to Treat Otitis Media via Sustained Transtympanic Delivery of Antibiotics'. Together they form a unique fingerprint.Projects
- 3 Active
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Partnership for Research and Education in Materials
Lodge, T. (PI) & Leighton, C. (Co-Principal Investigator)
UNIVERSITY OF TEXAS RIO GRANDE VALLEY, THE NATIONAL SCIENCE FOUNDATION
7/1/21 → 6/30/27
Project: Research project
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University of Minnesota Materials Research Science and Engineering Center (DMR-2011401)
Leighton, C. (PI) & Lodge, T. (CoI)
THE NATIONAL SCIENCE FOUNDATION
9/1/20 → 8/31/26
Project: Research project
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IRG-2: Mesoscale Network Materials
Mahanthappa, M. (Senior Investigator), Bates, F. S. (Senior Investigator), Calabrese, M. A. (Senior Investigator), Dorfman, K. (Senior Investigator), Ellison, C. J. (Senior Investigator), Ferry, V. E. (Senior Investigator), Lozano, K. (Senior Investigator), Reineke, T. M. (Senior Investigator) & Siepmann, I. (Senior Investigator)
9/1/20 → 8/31/26
Project: IRG