A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis

Wen Hai Shao; Yuxuan Zhen; Joshua Rosenbaum; Robert A. Eisenberg; Tracy L. McGaha; Mark Birkenbach; Philip L. Cohen

doi:10.1016/j.clim.2010.04.002

A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis

Wen Hai Shao, Yuxuan Zhen, Joshua Rosenbaum, Robert A. Eisenberg, Tracy L. McGaha, Mark Birkenbach, Philip L. Cohen

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. In the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that downregulates inflammation.

Original language	English (US)
Pages (from-to)	236-244
Number of pages	9
Journal	Clinical Immunology
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/j.clim.2010.04.002
State	Published - Aug 2010
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grants from the NIDCR and the US Department of Veterans Affairs.

Keywords

Apoptotic clearance
Cytokine regulation
Glomerulonephritis
MerTK

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clim.2010.04.002

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title = "A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis",

abstract = "The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. In the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that downregulates inflammation.",

keywords = "Apoptotic clearance, Cytokine regulation, Glomerulonephritis, MerTK",

author = "Shao, {Wen Hai} and Yuxuan Zhen and Joshua Rosenbaum and Eisenberg, {Robert A.} and McGaha, {Tracy L.} and Mark Birkenbach and Cohen, {Philip L.}",

note = "Funding Information: This work was supported by grants from the NIDCR and the US Department of Veterans Affairs.",

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doi = "10.1016/j.clim.2010.04.002",

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volume = "136",

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AU - Shao, Wen Hai

AU - Zhen, Yuxuan

AU - Rosenbaum, Joshua

AU - Eisenberg, Robert A.

AU - McGaha, Tracy L.

AU - Birkenbach, Mark

AU - Cohen, Philip L.

N1 - Funding Information: This work was supported by grants from the NIDCR and the US Department of Veterans Affairs.

PY - 2010/8

Y1 - 2010/8

N2 - The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. In the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that downregulates inflammation.

AB - The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. In the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that downregulates inflammation.

KW - Apoptotic clearance

KW - Cytokine regulation

KW - Glomerulonephritis

KW - MerTK

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ER -

A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis

Abstract

Bibliographical note

Keywords

UN SDGs

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