A progressive-ILP-based routing algorithm for the synthesis of cross-referencing biochips

Ping Hung Yuh, Sachin S Sapatnekar, Chia Lin Yang, Yao Wen Chang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Due to recent advances in microfluidics technology, digital microfluidic biochips and their associated computeraided-design problems have gained much attention, most of which has been devoted to direct-addressing biochips. In this paper, we solve the droplet routing problem under the more scalable cross-referencing biochip paradigm. We propose the first droplet routing algorithm that directly solves the problem of routing. We first present an optimal basic integer-linear-programming (ILP) formulation. Due to its complexity, we also propose a progressive-ILP scheme to determine the locations of droplets at each time step. Simulation results demonstrate the efficiency and effectiveness of our algorithm.

Original languageEnglish (US)
Pages (from-to)1295-1306
Number of pages12
JournalIEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Issue number1
StatePublished - Jan 1 2009


  • Cross-referencing biochips
  • Integer linear programming (ILP)
  • Progressive
  • Routing


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