A primer on chimeric antigen receptor t-cell therapy what does it mean for pathologists?

Allison M. Cushman-Vokoun, Karl V. Voelkerding, Mark K. Fung, Jan A. Nowak, John A. Thorson, Helena L. Duncan, Tanja Kalicanin, Matthew W. Anderson, Sophia Yohe

Research output: Contribution to journalArticlepeer-review

Abstract

Context.-Chimeric antigen receptor T-cell (CAR-T) technology has shown great promise in both clinical and preclinical models in mediating potent and specific antitumor activity. With the advent of US Food and Drug Administration-approved CAR-T therapies for B-cell lymphoblastic leukemia and B-cell non-Hodgkin lymphomas, CAR-T therapy is poised to become part of mainstream clinical practice. Objective.-To educate pathologists on CAR-T and chimeric antigen receptor-derived cellular therapy, provide a better understanding of their role in this process, explain important regulatory aspects of CAR-T therapy, and advocate for pathologist involvement in the delivery and monitoring of chimeric antigen receptor-based treatments. Much of the focus of this article addresses US Food and Drug Administration-approved therapies; however, more general issues and future perspectives are considered for therapies in development. Design.-A CAR-T workgroup, facilitated by the College of American Pathologists Personalized Health Care Committee and consisting of pathologists of various backgrounds, was convened to develop a summary guidance paper for the College of American Pathologists Council on Scientific Affairs. Results.-The workgroup identified gaps in pathologists' knowledge of CAR-T therapy, including uncertainty in the role of the clinical laboratory in supporting CAR-T therapy. The workgroup considered these issues and summarized the findings to assist pathologists to become stakeholders in CAR-T therapy administration. Conclusions.-This manuscript serves to both educate pathologists on CAR-T therapy and serve as a point of initial discussions in areas of CAR-T science, clinical therapy, and regulatory issues as CAR-T therapies continue to be introduced into clinical practice.

Original languageEnglish (US)
Pages (from-to)704-716
Number of pages13
JournalArchives of Pathology and Laboratory Medicine
Volume145
Issue number6
DOIs
StatePublished - Nov 25 2020

Bibliographical note

Publisher Copyright:
© 2021 College of American Pathologists. All rights reserved.

PubMed: MeSH publication types

  • Journal Article

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