A practical and scalable process to selectively monofunctionalize water-soluble α,ω-diols

Quanxuan Zhang, Hong Ren, Gregory L. Baker

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A practical protocol for rapid and scalable synthesis of monofunctionalized α,ω-diols using a simple and inexpensive THP ether protection/deprotection strategy was described. Use of inexpensive DHP source and ease to remove excess water-soluble α,ω-diols and THP ether after deprotection render the process scale-friendly without need of column chromatographic separation. The application of present method was also illustrated in the preparation of heterobifunctional diols and well-defined extended oligo(ethylene glycol).

Original languageEnglish (US)
Pages (from-to)3384-3386
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number22
DOIs
StatePublished - May 28 2014

Keywords

  • Monofunctionalization
  • Scalable
  • THP ether protection and deprotection
  • Water-soluble α,ω-diols

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