A practical and scalable manufacturing process for an antifungal agent, nikkomycin Z

Christopher J. Stenland, Lev G. Lis, Frederick J. Schendel, Nicholas J. Hahn, Mary A. Smart, Amy L. Miller, Marc G. Von Keitz, Vadim J. Gurvich

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A scalable and reliable manufacturing process for nikkomycin Z HCl on a scale of 170 g has been developed and optimized. The process is characterized by a 2.3 g/L fermentation yield, 79% purification yield, and >98% relative purity of the final product. This method is suitable for further scale-up and cGMP production. The Streptomyces tendae ΔNikQ strain developed during the course of this study is superior to any previously reported strain in terms of higher yield and purity of nikkomycin Z.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalOrganic Process Research and Development
Volume17
Issue number2
DOIs
StatePublished - Feb 15 2013

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    Stenland, C. J., Lis, L. G., Schendel, F. J., Hahn, N. J., Smart, M. A., Miller, A. L., Von Keitz, M. G., & Gurvich, V. J. (2013). A practical and scalable manufacturing process for an antifungal agent, nikkomycin Z. Organic Process Research and Development, 17(2), 265-272. https://doi.org/10.1021/op3003294