A powder tabletability equation

Gerrit Vreeman; Changquan Calvin Sun

doi:10.1016/j.powtec.2022.117709

A powder tabletability equation

Gerrit Vreeman, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An equation describing tablet tensile strength as a function of compaction pressure was derived from the Ryshkewitch and Kuentz-Leuenberger equations. The equation was used to fit data from 11 powders, including single-component powders and mixtures, with a wide range of mechanical properties. Three fitted parameters are obtained directly from tensile strength-compaction pressure data, of which one describes the apparent bonding strength and another strongly correlates with the plasticity.

Original language	English (US)
Article number	117709
Journal	Powder Technology
Volume	408
DOIs	https://doi.org/10.1016/j.powtec.2022.117709
State	Published - Aug 2022

Bibliographical note

Funding Information:
Funding from the National Science Foundation through grant number IIP- 1919037 is gratefully acknowledged for partially supporting G.V.

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

Mechanical properties
Tabletability
Tableting
Tensile strength

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10.1016/j.powtec.2022.117709

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title = "A powder tabletability equation",

abstract = "An equation describing tablet tensile strength as a function of compaction pressure was derived from the Ryshkewitch and Kuentz-Leuenberger equations. The equation was used to fit data from 11 powders, including single-component powders and mixtures, with a wide range of mechanical properties. Three fitted parameters are obtained directly from tensile strength-compaction pressure data, of which one describes the apparent bonding strength and another strongly correlates with the plasticity.",

keywords = "Mechanical properties, Tabletability, Tableting, Tensile strength",

author = "Gerrit Vreeman and Sun, {Changquan Calvin}",

note = "Funding Information: Funding from the National Science Foundation through grant number IIP- 1919037 is gratefully acknowledged for partially supporting G.V. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

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doi = "10.1016/j.powtec.2022.117709",

language = "English (US)",

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AU - Vreeman, Gerrit

AU - Sun, Changquan Calvin

N1 - Funding Information: Funding from the National Science Foundation through grant number IIP- 1919037 is gratefully acknowledged for partially supporting G.V. Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/8

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N2 - An equation describing tablet tensile strength as a function of compaction pressure was derived from the Ryshkewitch and Kuentz-Leuenberger equations. The equation was used to fit data from 11 powders, including single-component powders and mixtures, with a wide range of mechanical properties. Three fitted parameters are obtained directly from tensile strength-compaction pressure data, of which one describes the apparent bonding strength and another strongly correlates with the plasticity.

AB - An equation describing tablet tensile strength as a function of compaction pressure was derived from the Ryshkewitch and Kuentz-Leuenberger equations. The equation was used to fit data from 11 powders, including single-component powders and mixtures, with a wide range of mechanical properties. Three fitted parameters are obtained directly from tensile strength-compaction pressure data, of which one describes the apparent bonding strength and another strongly correlates with the plasticity.

KW - Mechanical properties

KW - Tabletability

KW - Tableting

KW - Tensile strength

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JO - Powder Technology

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ER -

A powder tabletability equation

Abstract

Bibliographical note

Keywords

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