A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Stephen M. Smith, Thomas E. Nichols, Diego Vidaurre, Anderson M. Winkler, Timothy E J Behrens, Matthew F. Glasser, Kamil Ugurbil, Deanna M. Barch, David C. Van Essen, Karla L. Miller

Research output: Contribution to journalShort survey

287 Scopus citations

Abstract

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

Original languageEnglish (US)
Pages (from-to)1565-1567
Number of pages3
JournalNature neuroscience
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2015

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    Smith, S. M., Nichols, T. E., Vidaurre, D., Winkler, A. M., Behrens, T. E. J., Glasser, M. F., Ugurbil, K., Barch, D. M., Van Essen, D. C., & Miller, K. L. (2015). A positive-negative mode of population covariation links brain connectivity, demographics and behavior. Nature neuroscience, 18(11), 1565-1567. https://doi.org/10.1038/nn.4125