A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis

Rodolphe Thuret, Maxine Sun, Lars Budaus, Firas Abdollah, Daniel Liberman, Shahrokh F. Shariat, François Iborra, Jacques Guiter, Jean Jacques Patard, Paul Perrotte, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Purpose: The association between marital status and tumor stage and grade, as well as overall mortality (OM) and cancer-specific mortality (CSM) received little attention in patients with squamous cell carcinoma of the penis (SCCP). Methods: We relied on the surveillance, epidemiology, and end results (SEER) 17 database to identify patients diagnosed with primary SCCP. Logistic and Cox regression models, respectively, addressed the effect of marital status on the rate of locally advanced disease and its effect on OM and CSM. Covariates consisted of age, race, socioeconomic status, year of surgery, and SEER registries. Results: Between 1988 and 2006, 1,884 patients with SCCP were identified. At surgery, 1,192 (63.3 %) were married and 966 (51.3 %) had locally advanced disease. In multivariable logistic regression models predicting locally advanced disease at surgery, unmarried men had a 1.5-fold higher (p < 0.001) risk than others. In multivariable Cox models predicting CSM, marital status had no effect [hazard ratio (HR) = 1.3, p = 0.1]. Finally, in multivariable Cox models predicting OM, unmarried men had a 1.3-fold higher (p = 0.001) risk than others. Conclusion: Unmarried men tend to present with less favorable disease stage at SCCP. Moreover, unmarried men tend to live less long than their married counterparts. However, marital status has no effect on CSM.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalCancer Causes and Control
Volume24
Issue number1
DOIs
StatePublished - Jan 2013

Bibliographical note

Funding Information:
Acknowledgments Pierre I. Karakiewicz is partially supported by the University of Montreal Health Center Urology Specialists, Fonds de la Recherche en Santé du Quebec, the University of Montreal Department Of Surgery and the University of Montreal Health Center (CHUM) Foundation. Rodolphe Thuret is partially supported by the Association Franc¸aise d’Urologie (AFU).

Keywords

  • Marital status
  • Penile carcinoma
  • Surveillance, epidemiology, and end results (SEER) program

Fingerprint Dive into the research topics of 'A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis'. Together they form a unique fingerprint.

Cite this