A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach

Wei Jhe Sun, Hongbo Chen, Aktham Aburub, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve CU and b) nanocoating HPMC to enhance flowability, we have developed a platform DC formulation for preparing low-dose drug sustained-release (SR) tablets with excellent CU. In addition to demonstrated robustness in manufacturability, this platform formulation has the flexibility for modifying drug release rate. Thus, it is useful for expedited and material-sparing development of low dose SR tablets using the economical DC process.

Original languageEnglish (US)
Pages (from-to)856-863
Number of pages8
JournalPowder Technology
Volume342
DOIs
StatePublished - Jan 15 2019

Bibliographical note

Funding Information:
This work was supported by a grant from Eli Lilly and Company through the Lilly Research Award Program. W-J. Sun is grateful to the Department of Pharmaceutics, University of Minnesota for a David and Marilyn Grant Fellowship in Physical Pharmacy (2015-2017) and the Dane O. Kildsig Center for Pharmaceutical Processing Research (CPPR) for partial financial support.

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

  • Acetaminophen
  • Celecoxib
  • Direct compression
  • Nanocoating
  • Nicotinamide
  • Particle engineering
  • Sustained release
  • Tableting

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