A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach

Wei Jhe Sun, Hongbo Chen, Aktham Aburub, Calvin Sun

Research output: Contribution to journalArticle

Abstract

Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve CU and b) nanocoating HPMC to enhance flowability, we have developed a platform DC formulation for preparing low-dose drug sustained-release (SR) tablets with excellent CU. In addition to demonstrated robustness in manufacturability, this platform formulation has the flexibility for modifying drug release rate. Thus, it is useful for expedited and material-sparing development of low dose SR tablets using the economical DC process.

LanguageEnglish (US)
Pages856-863
Number of pages8
JournalPowder Technology
Volume342
DOIs
StatePublished - Jan 15 2019

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Tablets
Composite materials
Drug Carriers
Pharmaceutical Preparations

Keywords

  • Acetaminophen
  • Celecoxib
  • Direct compression
  • Nanocoating
  • Nicotinamide
  • Particle engineering
  • Sustained release
  • Tableting

Cite this

A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach. / Sun, Wei Jhe; Chen, Hongbo; Aburub, Aktham; Sun, Calvin.

In: Powder Technology, Vol. 342, 15.01.2019, p. 856-863.

Research output: Contribution to journalArticle

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