A plastidial retrograde signal potentiates biosynthesis of systemic stress response activators

Liping Zeng, Jin Zheng Wang, Xiang He, Haiyan Ke, Mark Lemos, William M. Gray, Katayoon Dehesh

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Plants employ an array of intricate and hierarchical signaling cascades to perceive and transduce informational cues to synchronize and tailor adaptive responses. Systemic stress response (SSR) is a recognized complex signaling and response network quintessential to plant’s local and distal responses to environmental triggers; however, the identity of the initiating signals has remained fragmented. Here, we show that both biotic (aphids and viral pathogens) and abiotic (high light and wounding) stresses induce accumulation of the plastidial-retrograde-signaling metabolite methylerythritol cyclodiphosphate (MEcPP), leading to reduction of the phytohormone auxin and the subsequent decreased expression of the phosphatase PP2C.D1. This enables phosphorylation of mitogen-activated protein kinases 3/6 and the consequential induction of the downstream events ultimately, resulting in biosynthesis of the two SSR priming metabolites pipecolic acid and N-hydroxy-pipecolic acid. This work identifies plastids as a major initiation site, and the plastidial retrograde signal MEcPP as an initiator of a multicomponent signaling cascade potentiating the biosynthesis of SSR activators, in response to biotic and abiotic triggers.

Original languageEnglish (US)
Pages (from-to)1732-1749
Number of pages18
JournalNew Phytologist
Volume233
Issue number4
DOIs
StatePublished - Feb 2022

Bibliographical note

Funding Information:
We would like to thank Professor Elizabeth Sattely at Stanford University for providing us with the chemically synthesized NHP standard. We would like to thank our colleagues at UCR: Professor Isgouhi Kaloshian and Dr Jacob Macwilliams for aphid-infested plants; and Dr Bailong Zhang for viral-infected plants. This work was supported by NSF CREATE-IGERT training program (NSF DGE-0653984) and NSF-GRFP 1148897 to ML, by Dr John W. Leibacher and Mrs Kathy Cookson endowed chair funds to KD, and by the National Institutes of Health (NIH; GM067203) to WMG, and by NIH (R01GM107311-8) grant to KD.

Funding Information:
We would like to thank Professor Elizabeth Sattely at Stanford University for providing us with the chemically synthesized NHP standard. We would like to thank our colleagues at UCR: Professor Isgouhi Kaloshian and Dr Jacob Macwilliams for aphid‐infested plants; and Dr Bailong Zhang for viral‐infected plants. This work was supported by NSF CREATE‐IGERT training program (NSF DGE‐0653984) and NSF‐GRFP 1148897 to ML, by Dr John W. Leibacher and Mrs Kathy Cookson endowed chair funds to KD, and by the National Institutes of Health (NIH; GM067203) to WMG, and by NIH (R01GM107311‐8) grant to KD.

Publisher Copyright:
© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

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