A plastidial retrograde signal potentiates biosynthesis of systemic stress response activators

Liping Zeng, Jin Zheng Wang, Xiang He, Haiyan Ke, Mark Lemos, William M. Gray, Katayoon Dehesh

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Plants employ an array of intricate and hierarchical signaling cascades to perceive and transduce informational cues to synchronize and tailor adaptive responses. Systemic stress response (SSR) is a recognized complex signaling and response network quintessential to plant’s local and distal responses to environmental triggers; however, the identity of the initiating signals has remained fragmented. Here, we show that both biotic (aphids and viral pathogens) and abiotic (high light and wounding) stresses induce accumulation of the plastidial-retrograde-signaling metabolite methylerythritol cyclodiphosphate (MEcPP), leading to reduction of the phytohormone auxin and the subsequent decreased expression of the phosphatase PP2C.D1. This enables phosphorylation of mitogen-activated protein kinases 3/6 and the consequential induction of the downstream events ultimately, resulting in biosynthesis of the two SSR priming metabolites pipecolic acid and N-hydroxy-pipecolic acid. This work identifies plastids as a major initiation site, and the plastidial retrograde signal MEcPP as an initiator of a multicomponent signaling cascade potentiating the biosynthesis of SSR activators, in response to biotic and abiotic triggers.

Original languageEnglish (US)
Pages (from-to)1732-1749
Number of pages18
JournalNew Phytologist
Issue number4
StatePublished - Feb 2022

Bibliographical note

Publisher Copyright:
© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation


Dive into the research topics of 'A plastidial retrograde signal potentiates biosynthesis of systemic stress response activators'. Together they form a unique fingerprint.

Cite this