A pilot study of the effects of a perflubron emulsion, AF 0104, on mixed venous oxygen tension in anesthetized surgical patients

Joyce A. Wahr, Adrianus Trouwborst, Richard K. Spence, Christian P. Henny, Aurel C. Cernaianu, Gregory P. Graziano, Kevin K. Tremper, Kathryn E. Flaim, Peter E. Keipert, N. Simon Faithfull, Janice J. Clymer

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

A pilot study of a perfluorochemical (PFC) emulsion was undertaken to determine whether administration of a perflubron emulsion could result in measurable changes in mixed venous oxygen tension. Seven adult surgical patients received a 0.9-g PFC/kg intravenous dose of perflubron emulsion after acute normovolemic hemodilution (ANH). Hemodynamic and oxygen transport data were collected before and after ANH, immediately after PFC infusion, and at approximate 15-min intervals throughout the surgical period. There were no clinically significant hemodynamic changes associated with the administration of the PFC emulsion. There was a significant increase in mixed venous oxygen tension (PVO2) after the PFC infusion, while cardiac output and oxygen consumption were unchanged. As surgery progressed, the hemoglobin concentration decreased with ongoing blood loss while PVO2 values remained at or above predosing levels. Peak perflubron blood levels were 0.8 g/dL immediately postinfusion, and approximately 0.3 g/dL at 1 h. This pilot study demonstrates that administration of perflubron emulsion results in measurable changes in mixed venous oxygen tension during intraoperative ANH.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalAnesthesia and analgesia
Volume82
Issue number1
DOIs
StatePublished - Jan 18 1996

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