Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD. LICI-200 showed the most significant associations with RS functional connectivity features, demonstrating its potential to evaluate the neurochemical underpinnings of network features in MDD.
Bibliographical noteFunding Information:
This research was supported by grants from the Brain and Behavior Research Foundation (Young Investigator Award 20883), the Mayo Clinic Foundation (Departmental Small Grant Award), and the National Institute of Mental Health ( K23 MH100266 and R01MH113700 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
GAW has received research support from Medtronic, Inc., Neuralynx, Inc., and Neuropace, Inc. PEC has received research grant support from Pfizer, Inc., has received equipment support from Neuronetics, Inc.; and receives supplies and genotyping services from Assurex Health, Inc. for an investigator-initiated study. He is the primary investigator for a multicenter study funded by Neuronetics, Inc. and a site primary investigator for a study funded by NeoSync, Inc. CPL is a site investigator on multicenter studies funded by Neuronetics, Inc. and NeoSync, Inc. IB, JS, JDP, and HJJ have no financial disclosures.
- Resting state
- TMS, fMRI