A pig with functional human immunity

Christopher K. Tuggle; Crystal L. Loving; Beau R. Webber

doi:10.1038/s41551-025-01426-4

A pig with functional human immunity

Christopher K. Tuggle
, Crystal L. Loving
, Beau R. Webber

Pediatric Hematology/Oncology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Genetically modified immunodeficient pigs support the development of functional human B and T cells and represent a preclinical model for investigating human haematopoiesis and a bioreactor for large-scale production of human immune cells for diverse therapies.

Original language	English (US)
Pages (from-to)	1565-1566
Number of pages	2
Journal	Nature Biomedical Engineering
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/s41551-025-01426-4
State	Published - Oct 2025

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© Springer Nature Limited 2025.

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title = "A pig with functional human immunity",

abstract = "Genetically modified immunodeficient pigs support the development of functional human B and T cells and represent a preclinical model for investigating human haematopoiesis and a bioreactor for large-scale production of human immune cells for diverse therapies.",

author = "Tuggle, \{Christopher K.\} and Loving, \{Crystal L.\} and Webber, \{Beau R.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2025.",

year = "2025",

month = oct,

doi = "10.1038/s41551-025-01426-4",

language = "English (US)",

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AU - Tuggle, Christopher K.

AU - Loving, Crystal L.

AU - Webber, Beau R.

N1 - Publisher Copyright: © Springer Nature Limited 2025.

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N2 - Genetically modified immunodeficient pigs support the development of functional human B and T cells and represent a preclinical model for investigating human haematopoiesis and a bioreactor for large-scale production of human immune cells for diverse therapies.

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U2 - 10.1038/s41551-025-01426-4

DO - 10.1038/s41551-025-01426-4

M3 - Comment/debate

C2 - 40500333

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JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

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ER -

A pig with functional human immunity

Abstract

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